ROLE OVERVIEW

We are seeking a highly skilled Senior Investigator in Antibody Discovery & Engineering (ADE) with expertise in molecular biology, protein production, purification and characterization. The successful candidate will design and execute experiments to produce and characterize proteins, with a focus on MultispecificTM antibodies to support discovery. You will be responsible for processing of mammalian-expressed recombinant proteins using state-of-the-art technologies and automated equipment. This role requires deep technical knowledge, strong problem-solving skills and the ability to collaborate across multidisciplinary teams. The successful candidates will join an innovative antibody/protein engineering department with a strong record of success in developing novel antibody therapeutics in the field of immuno-oncology. The position is laboratory-based within the Protein Sciences group.

RESPONSIBILITIES

• Design and optimize DNA vectors and constructs for protein expression across multiple systems (including HEK, CHO, and E. coli).
• Establish and improve transient and stable transfection protocols to optimize protein yield and quality.
• Purify and characterize candidate antibodies and target proteins using different chromatographic approaches (e.g. Protein A, CEX, SEC, IMAC).
• Characterize antibody candidates using analytical methods (e.g. SDS-PAGE, SEC, IEF, cGE, HIC, Nano DSF/DLS) 
• Assess protein functionality using advanced analytical methods (e.g. SPR)
• Be a hands-on presence in the laboratory
• Perform data analysis and documentation
• Write formal technical reports, methods and procedures
• Accomplish goals under project team timelines
• Communicate effectively and in a timely manner protein production status and research progress to senior management
• Present results during internal meetings
• Support a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates
• Comply with HSE guidelines

EDUCATION AND DESIRED EXPERIENCE

• Ph.D., MSc or BSc degree in Biochemistry, Cell biology, Biotechnology, or a related discipline with demonstrated capabilities in protein expression, purification and analytical characterization. Industry experience in antibody production/characterization is preferred.
• Proficiency in molecular biology techniques (PCR, vector design, cloning, primer design) and DNA sequence analysis software is required.
• Hands-on experience in protein production, purification and characterization (practical knowledge of HPLC and/or AKTA protein purification systems is preferred).
• Hands-on experience in cell culture is preferred.
• Knowledge in Design of Experiment and statistical analysis is a plus.
• Scientific curiosity, problem solving abilities, capacity to plan experiments and analyze results.
• Self-motivated team player with strong organization skills.
• Able to work with flexibility in a changing and demanding research environment
• Professional level in English, both written and verbal.