Investigator - Antibody Engineering - Biophysics Team
ROLE OVERVIEW
We are seeking a highly skilled Investigator in Antibody Discovery & Engineering (ADE) with expertise in molecular biology, protein production and analytics to support discovery activities. The successful candidate will support screening, expression and characterization of mono and multi-specific antibodies. This role requires deep technical knowledge, strong problem-solving skills and the ability to collaborate across multidisciplinary teams. The position is laboratory-based within the Biophysics Team of the Antibody Discovery & Engineering Department. The successful candidate will join an innovative antibody/protein engineering department with a strong record of success in developing novel antibody therapeutics in the field of immuno-oncology.
RESPONSIBILITIES
- Clone, express in mammalian cells, and purify therapeutic antibodies
- Characterize antibody candidates using analytical methods (e.g. SDS-PAGE, SEC, HIC, Nano DSF/DLS, DSC, IEF)
- Characterize antibody candidates using biophysical and developability assessment assays (e.g. AC-SINS, polyreactivity ELISA)
- Develop and perform protein-protein interaction assays, including kinetic, epitope binning, blocking assays (ELISA, SPR, Carterra LSA, BLI)
- Implement new technologies as required to improve efficiency of the group (e.g. high-throughput SE-UPLC, automation)
- Be a hands-on presence in the laboratory
- Perform data analysis and documentation
- Write formal technical reports, methods and procedures
- Accomplish goals under project team timelines
- Communicate effectively and in a timely manner activities status and research progress to senior management
- Present results during internal meetings
- Support a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates
- Comply with HSE guidelines
EDUCATION AND DESIRED EXPERIENCE
- MSc or BSc degree in Biochemistry, Structural Biology, Biotechnology or a related discipline is required. Industry experience in antibody characterization is preferred
- Proficiency in molecular biology techniques (PCR, cloning, primer design) and DNA sequence analysis software is required.
- Hands-on experience in protein production, purification and characterization (practical knowledge of HPLC and/or AKTA protein purification systems is preferred)
- Experience with protein-protein interaction methods (SPR, BLI or related technologies), hands-on experience with Biacore and/or Octet systems is desirable
- Hands-on experience in cell culture is preferred.
- Knowledge in Design of Experiment and statistical analysis is a plus.
- Scientific curiosity, problem solving abilities, capacity to plan experiments and analyze results.
- Self-motivated team player with strong organization skills.
- Able to work with flexibility in a changing and demanding research environment
- Professional level in English, both written and verbal.